Association of vascular endothelial growth factor gene polymorphisms with recurrent spontaneous abortion in Chinese Han women
Xing, X.; Yan, J.; Zhao, Y.; You, L.; Bian, Y.; Chen, Z-Jiang.
American Journal of Reproductive Immunology 65(5): 521-525
2011
ISSN/ISBN: 1046-7408 PMID: 20950367 DOI: 10.1111/j.1600-0897.2010.00924.xDocument Number: 222667
An association of polymorphism -1154G/A (rs1570360) in vascular endothelial growth factor (VEGF) gene with idiopathic recurrent spontaneous abortion (RSA) has been found in Caucasians. The aim of this study was to examine the association of VEGF -1154 with RSA in a well-defined group of Chinese Han patients. The VEGF -1154G/A genotype was detected by real-time PCR with TaqMan probes. The products were also subjected to gene sequence analysis to validate the PCR results. The allele frequencies of VEGF -1154G/A showed no significant difference between RSA patients and the normal controls (P = 0.183). The frequencies of VEGF -1154G/A genotypes were not significantly different between RSA patients and the normal controls (P = 0.228). Our study revealed that VEGF -1154G/A polymorphism was not associated with the susceptibility to RSA in Chinese Han women.