Tissue sensitivity to acetylcholine, adrenaline, noradrenaline and serotonin and agents acting on sulphydryl groups
Tongia, S.K.; Pandya, K.
Indian Journal of Physiology and Pharmacology 28(2): 141-144
1984
ISSN/ISBN: 0019-5499 PMID: 6511063 Document Number: 222144
Parachloromercury benzoate (PCMB), a sulfhydryl inactivator, caused a progressively increasing inhibition of and serotonin in vitro. This inhibition was progressively and completely reversed by penicillamine, a sulfhydryl activator. It is inferred that intact sulfhydryl groups are essential for constancy of responses of excitable tissues to the neurotransmitters.