Determination of reference intervals of HbA1C (DCCT/NGSP) and HbA1C (IFCC) in adults
Charuruks, N.; Milintagas, A.; Watanaboonyoungcharoen, P.; Ariyaboonsiri, C.
Journal of the Medical Association of Thailand 88(6): 810-816
2005
ISSN/ISBN: 0125-2208 PMID: 16083221 Document Number: 2220
Objective: To establish HbA(1C) reference intervals according to DCCT/NGSP (HbA(1C) DCCT/NGSP) and IFCC (HbA(1C)IFCC) in adults.Study Design: The study was a descriptive study.Material and Method: The study was done in 144 subjects, with 99 males and 45 females, aged between 19 to 78 years old All subjects had normal vital signs, physical examination, chest X-ray. Subjects who had hyperglycemia, renal problem, liver problem, anemia, and/or hemoglobinopathy were excluded from the present study.Results: Reference intervals of HbA(1C) (DCCT/NGSP) is 5.47% (4.79-6.15) and HbA(1C) (IFCC) is 3.66% (2.88-4.44). The authors also found very high correlation between HbA(1C) (DCCT/NGSP) and HbA(1C) (IFCC) of total, male, female, < 35 years old, and >= 35 years old, r = 0.9995, 09997, 0.9992, 0.9988, and 0.9999, respectively.Conclusion: The authors found that HbA(1C) (DCCT/NGSP) and HbA(1C) (IFCC) are not affected by sex but are influenced significantly by age group. Since HbA(1C) (IFCC) will be widely used in routine diabetes management, the authors recommend all laboratories provide the results of HbA(1C) in both DCCT/NGSP and IFCC methods during this interim period.
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