Insulin resistance in uraemia. An insulin receptor or an intracellular defect?
Schmitz, O.; Hasling, C.; Hjøllund, E.; Hansen, H.E.; Posborg Petersen, V.; Beck-Nielsen, H.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 20: 686-691
1983
ISSN/ISBN: 0071-2736 PMID: 6657689 Document Number: 220859
The present study was designed to determine the participation of a decreased insulin binding versus that of a post-binding defect in uraemic insulin resistance and to examine the possible effect of dialysis treatment. This was done by constructing an in vivo insulin dose-response curve using the euglycaemic clamp technique. We found that the maximal responsiveness to insulin was decreased in uraemic patients. Long-term dialysis treatment improved the maximum glucose metabolism significantly (7.7. +/- 0.7 mg/kg/min versus 10.7 +/- 0.6 mg/kg/min, p less than 0.01). On the contrary we found no clearcut alteration of the half-maximal insulin concentrations in relation to dialysis. In conclusion, this report indicates that the insulin resistance in uraemia is primarily due to post-binding defects, i.e. an impaired intracellular glucose metabolism or an abnormal glucose transport system.