Multiple endocrine abnormalities in Basenji dogs with renal tubular dysfunction
Breitschwerdt, E.B.; Ochoa, R.; Waltman, C.
Journal of the American Veterinary Medical Association 182(12): 1348-1353
1983
ISSN/ISBN: 0003-1488 PMID: 6687336 Document Number: 220650
Three Basenji dogs with renal tubular dysfunction were studied. Hyposthenuria and diminished urine concentrating ability, indicative of nephrogenic diabetes insipidus, were found. Metabolic acidosis, hyperchloraemia, and reduction in glomerular filtration rate also were detected in all dogs. In addition, an exaggerated response to the adrenocorticotropin test and hyperaldosteronism, believed to be secondary to decreased effective cirulating blood volume, were detected in all three dogs. Thyroxine values were decreased in all dogs and could be correlated with histopathological changes of the thyroid gland in two dogs. Gastropathy and hypergastrinaemia were identified in two dogs. Diffuse lymphocytic-plasmacytic enteritis was evident in two dogs. It is concluded that a urine concentrating defect that may be secondary to hypercortisolism exists in Basenji dogs with renal tubular dysfunction.