Combined oral contraceptives in women with menstrual migraine without aura
De Leo, V.; Scolaro, V.; Musacchio, M.C.; Di Sabatino, A.; Morgante, G.; Cianci, A.
Fertility and Sterility 96(4): 917-920
2011
ISSN/ISBN: 1556-5653 PMID: 21843889 DOI: 10.1016/j.fertnstert.2011.07.1089Document Number: 219928
To compare the efficacy of two regimens (21 active pills + 7 placebo pills vs. 24 active pills + 4 placebo pills) of combined oral contraception (COC), both containing 20 μg of ethinyl E(2) and 3 mg of drospirenone, in improving the severity of pure menstrual migraine without aura. Prospective randomized study. Patients attending the gynecology department of the University of Siena for consultation regarding an appropriate contraception. Women ages 20 to 35 years (n = 60) suffering from pure menstrual migraine without aura. Three months of contraceptive use (ethinyl E(2) 20 μg/drospirenone 3 mg) in two different regimens: group A received 21 active + 7 placebo pills whereas group B received 24 active + 4 placebo pills. Monthly evaluation of the duration and severity of patients' daily headache attacks. Although both study groups demonstrated significant reduction in the intensity and duration of menstrual migraine, patients in group B (24/4 COC) reported a significant reduction in the intensity and a shorter duration of their menstrual migraine, compared with group A (21/7 COC). The 24/4 COC regimen is recommended as the preferred treatment for patients suffering from pure menstrual migraine without aura.
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