Effect of the joint use of BCG and antithymocyte serum on the growth of a syngeneic tumor in mice
Babadzhanov, A.S.; Slavina, E.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 95(2): 68-70
1983
ISSN/ISBN: 0365-9615 PMID: 6600630 Document Number: 219612
The growth of the syngeneic tumor Acatol in BALB/c mice was retarded if the animals were pretreated with BCG or antilymphocyte serum (ATS). Combined use of BCG and ATS led to a significantly more powerful retardation as compared to the effect produced by each factor alone. Using the adoptive transfer of splenocytes from treated mice it was shown that tumor growth suppression is effected by the cell types other than T lymphocytes and macrophages. It is probable that the effector cells within the given system are K cells and natural killer cells. The results attest to a possibility of search for a two-directional action on the immune system of the tumor host, which would stimulate antitumor effector cells and inhibit the activity of suppressors, particularly that of T suppressors.