Effects of oral contraceptives on natriuretic peptide levels in women with hypothalamic amenorrhea: a pilot study
Lin, E.; Grinspoon, S.; Wang, T.; Miller, K.K.
Fertility and Sterility 95(8): 2605-2607
2011
ISSN/ISBN: 1556-5653 PMID: 21620395 DOI: 10.1016/j.fertnstert.2011.04.064Document Number: 219605
Natriuretic peptides, which are important regulators of salt handling and blood pressure, are 60%-75% higher in healthy young women than in men, consistent with a gender dimorphism. In this randomized, placebo-controlled study in women with functional hypothalamic amenorrhea, we show that administration of oral contraceptives (OC) increases natriuretic peptide levels and that end-of-study free T levels are inversely associated with amino-terminal pro-B-type natriuretic peptide levels, consistent with the hypothesis that natriuretic peptide levels may be mediated by differences in gonadal steroid concentrations-estrogens (E) or androgens.
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