Antidiuretic hormone inhibitor in the cells of the frog bladder and its sorption
Shakhmatova, E.I.; Lukichev, B.G.; Natochin, I.V.; Riabov, C.I.; Emanuel', V.L.
Problemy Endokrinologii 29(2): 75-78
1983
ISSN/ISBN: 0375-9660 PMID: 6304682 Document Number: 219584
The H2O flow according to the osmotic gradient increased under the action of 1 mU/ml of antidiuretic hormone (ADH) from 0.049 .+-. 0.017 to 1.31 .+-. 0.29 .mu.l/cm2 min in the presence of a hemosorbent in frog bladder serous membrane and from 0.054 .+-. 0.015 to 0.67 .+-. 0.15 .mu.l/cm2 min without a sorbent. The effect of polyethylene glycol 400 hyperosmotic solution on the water, cAMP and theophylline penetration was not intensified after hemosorbent use. ADH inhibitor-binding substances are present in the blood serum. ADH enhances the water penetration, stimulating at the same time the release of the inhibitor, lowering its interaction with the receptor. Such a self-regulation is absent in the presence of hemosorbent, absorbing ADH inhibitor.