Marrow neutrophil mass in patients with nonhematological tumor
Liu, Y.K.; Kosfeld, R.E.; Koo, V.
Journal of Laboratory and Clinical Medicine 101(4): 561-568
1983
ISSN/ISBN: 0022-2143 PMID: 6833827 Document Number: 218425
The state of granulocytopoiesis was assessed in 15 patients with metastatic carcinoma without infection, overt protein-calorie malnutrition, splenomegaly or prior chemotherapy. Seven patients had decreased total marrow neutrophil mass, accompanied by proportional reduction in marrow proliferative and nonproliferative neutrophil pool, without increased numbers or proliferative capacity of marrow CFC assessed with hydrocortisone, but only one had reduced marrow nonproliferative neutrophil pool. Neither MGR nor blood neutrophil count correlates significantly with nonproliferative neutrophil pool or the number of band and segmented neutrophils in the bone marrow. The blood neutrophil count correlates significantly with total marrow neutrophil mass (r = 0.69 P < 0.01) and proliferative neutrophil pool (r = 0.68, P < 0.01). Reduced marrow neutrophil mass is apparently common in patients with matastatic carcinoma in the absence of overt protein-calorie malnutrition, and the reduced marrow neutrophil mass is most likely due to depressed granulocytopoiesis.