Comparative study of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on hemodynamics in pregnant dogs
Murayama, K.; Kasai, H.; Adachi, T.; Utsunomiya, O.; Ouchi, H.
Nihon Sanka Fujinka Gakkai Zasshi 35(3): 344-350
1983
ISSN/ISBN: 0300-9165 PMID: 6339650 Document Number: 218182
Effects of intravenous injections of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), renal blood flow (RBF), and uterine blood flow (UBF) were investigated in the anesthetized pregnant dog. A dose-dependent fall in MAP was observed with these two agents. HR was almost unchanged by both PG I2 and TXA2 synthetase inhibitor. PG I2 and TXA2 synthetase inhibitor produced increases in CO and RBF in a dose-dependent manner. PG I2 caused a dose-dependent decrease in UBF, while TXA2 synthetase inhibitor was followed by an insignificant decrease in UBF. PG I2 and TXA2 synthetase inhibitor did not induce any increase in intrauterine pressure (IUP). The possibility of treatment of pregnancy-induced hypertension with PG I2 or TXA2 synthetase inhibitor is discussed.