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Pretransplant antibodies and renal allograft survival

MacLeod, A.M.; Mason, R.J.; Power, D.A.; Edward, N.; Stewart, K.N.; Shewan, G.; Catto, G.R.

Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 20: 305-308

1983

ISSN/ISBN: 0071-2736
PMID: 6361743
Document Number: 218098
Fc receptor blocking antibodies directed against autologous lymphocytes were present in pretransplant sera from only one of a group of 24 cadaver donor renal transplant recipients. Such antibodies were present in recipient sera against B lymphocytes from the donor in 11/24, against normal B lymphocytes in 12/24 and against leukaemic B lymphocytes in 15/24 cases. There was a significant correlation between EA inhibiting antibodies directed against donor (p less than 0.01), normal (p less than 0.05) and leukaemic B lymphocytes (p less than 0.001) and improved one year allograft survival. No autolymphocytotoxic antibodies were detected. Fc receptor blocking antibodies detected by the Erythrocyte Antibody Inhibition assay may thus have a beneficial effect on graft outcome but do not appear to be autoantibodies.

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