Cytogenesis and cytomorphology of the Hodgkin- and Sternberg-Reed cells
Stobbe, H.
Archiv für Geschwulstforschung 53(2): 115-123
1983
ISSN/ISBN: 0003-911X PMID: 6190461 Document Number: 217971
As well the pathogenesis of the lymphogranulomatosis, the cytogenesis of the Hodgkin- and Sternberg-Reed-cells is still an unsolvable problem too. The priority in the discussion of this question have such hypothesis, in which a descend of these cells either from the lymphocytic or the monocyte-macrophage-system is important. The karyokinesis of the Hodgkin cells leads actually to the growth of the nucleus and the whole cell, but the formation of the Sternberg-Reed-cells in their property as gigantic cells means a "blind alley", connected with a blockade in their farther proliferation. The cytomorphology of the Hodgkin-cells and the causes for the formation of the Sternberg-Reed-cells with their multiform, partial bizarre nuclei will be discussed. In the consequence of anomalies of the mitosis, produced by so called disturbances of the spindle, several "partial nuclei" arise. These partial nuclei have the property to make partly a fusion together. In this connection the different shapes of the nuclei of the Sternberg-Reed-cells will be explained.