Stratum of the population of the Bashkir ASSR with natural immunity to hemorrhagic fever with renal syndrome

Miasnikov, I.A.; Tkachenko, E.A.; Rezapkin, G.V.; Dzagurova, T.K.; Urazbaeva, A.A.

Voprosy Virusologii 28(5): 573-577


ISSN/ISBN: 0507-4088
PMID: 6140792
Document Number: 217670
Natural immunity to hemorrhagic fever with the renal syndrome (HFRS) in the human population of the Bashkir ASSR having the highest incidence of this infection was first studied using radioimmunoassay. The antigen was a suspension of lungs of rodents from natural foci containing high antigen titres. When 1726 human sera from 8 districts and 2 towns were examined, antibodies to HFRS were found in 20.1%, with variations from 6.9% to 41.5% in different territories. No relationship between the percentage of immune subjects and average incidence values for 17 years was found. In the immune population, men accounted for 21.3%, women for 19.3%. Among subjects under 40, the immune stratum was lower (17.5%) than among older subjects (26.2%). The percentage of immunity was found to depend on the occupation of the population. No significant difference in immunity could be found in persons with different blood groups. Antibody in HFRS convalescent was shown to persist in high titres for up to 20 years after the onset of the disease.

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