Effects of calcitonin on the renal concentrating mechanism
de Rouffignac, C.; Elalouf, J.M.
American Journal of Physiology 245(4): F506-F511
1983
ISSN/ISBN: 0002-9513 PMID: 6624911 Document Number: 217604
Effects of salmon calcitonin on the renal concentrating mechanism were investigated in homozygous DI osmol = 1.85 .+-. 0.14) and simultaneously absolute and fractional water excretion fell significantly despite the concomitant rise in the glomerular filtration rate. In the hormone-deprived animal, calcitonin administration consistently enhances the corticomedullary concentration gradient. Effects of hormone deprivation and calcitonin administration on the urinary concentrating mechanism are compatible with direct stimulation by calcitonin of electrolyte reabsorption along the thick ascending limb and/or of the water permeability of the cortical collecting ducts.