The syndrome of gastric argyrophil carcinoid tumors and nonantral gastric atrophy
Carney, J.A.; Go, V.L.; Fairbanks, V.F.; Moore, S.B.; Alport, E.C.; Nora, F.E.
Annals of Internal Medicine 99(6): 761-766
1983
ISSN/ISBN: 0003-4819 PMID: 6197001 Document Number: 216555
Records of the 30 cases of gastric carcinoid at the Mayo Clinic [Rochester, Minnesota, USA] showed that the gastric mucosa was normal, hyperplastic or atrophic (nonantral) in 12, 2, or 16 patients, respectively. In the atrophic group, the tumors were in the gastric body and fundus; small, polypoid and multicentric; and associated with fundal argyrophil cell hyperplasia. In immunocytochemical studies, minor tumor cell populations stained positively for 5-hydroxytryptamine, gastrin and somatostatin in 1 case and for 5-hydroxytryptamine in 3 others. Metastasis occurred in 3 patients. Twelve patients had pernicious anemia. Parietal cell or intrinsic factor antibodies or both were present in all 12 patients tested. Each of the 7 patients with an intact antrum had massive hypergastrinemia. No common HLA-A, -B or -DR antigen pattern was detected among the 10 patients tested. Nonantral gastric atrophy apparently predisposes to gastric carcinoid and to gastric carcinoma.