A controlled clinical trial of iohexol and diatrizoate in aortofemoral angiography
Egsgaard, H.; Hørup, A.; Praestholm, J.
European Journal of Radiology 3(1): 14-17
1983
ISSN/ISBN: 0720-048X PMID: 6341063 Document Number: 216425
Iohexol is a recently synthesized non-ionic low-osmolar contrast medium. It has been compared to the conventional ionic hyperosmolar contrast medium diatrizoate (Urografin 60%) in a randomized double-blind crossover study of aortofemoral angiographies of 50 consecutive patients. The intraarterial blood pressures, the pulse rate and ECG were recorded continuously and the reactions of pain and warmth were evaluated. Iohexol caused significantly less haemodynamic changes than Urografin and also the pain reactions were significantly reduced. The quality of the angiograms was equal.