Cancer immunotherapeutics: raising the ante
Thorat, M.A.; Datar, R.H.; Joshi, N.N.
National Medical Journal of India 19(3): 140-150
2006
ISSN/ISBN: 0970-258X PMID: 16836264 Document Number: 2153
Therapeutically, cancer is one of the most challenging diseases. This is due to the inherent heterogeneity of malignant cells. The degree of plasticity of response stemming from genotypic and phenotypic diversity among the cancer cells allows their dynamic evolution into non-responsive or resistant variants. This phenomenon necessitates the simultaneous or sequential use of multiple therapeutic agents. The use of immunotherapeutic modalities as adjuvants is gaining increasing importance not only due to their highly specific therapeutic potential but also for their vaccine-like effects which could yield long term benefits. Increasing efforts are therefore ongoing to evolve and incorporate immunological approaches into effective clinical treatments.
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