Oral contraceptive and anesthesia
Yamamoto, K.
Masui. Japanese Journal of Anesthesiology 59(9): 1166-1170
2010
ISSN/ISBN: 0021-4892 PMID: 20857676 Document Number: 213999
Current oral contraceptive (OCs) use is associated with a fivefold increased risk of perioperative venous thromboembolism (VTE). Although the absolute number of patient who develops perioperative VTE when taking OCs is small (15-25 per 100,000 person-years), the newer OC contains desogestrel as progestogen (the third generation OC) is found to have slightly greater risk of VTE than the older OCs. "WHO criteria for the use of oral contraceptive, third edition (2004)" classifies only the major surgery with prolonged immobilization as "Category 4" where oral contraceptive is not to be used. On the contrary, Japanese Ministry of Health, Labour and Welfare prohibits OCs in all kinds of surgery. Although the restraint of perioperative OCs administration is invalid, it would be prudent to halt perioperative OCs in Japan.
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