Physiology of resuscitation
Winegar, C.D.; White, B.C.
Emergency Medicine Clinics of North America 1(3): 479-499
1983
ISSN/ISBN: 0733-8627 PMID: 6441702 Document Number: 213843
Ischemia ultimately leads to loss of thermodynamic order in all cells. During ischemia and reperfusion, the influx of Ca2+ ions appears to initiate a number of cell processes, the reversal of which depends on the re-establishment and maintenance of adequate organ perfusion and high energy metabolism. Promising therapeutic approaches for accomplishing these goals include substrate augmentation, inhibition of calcium-activated injury, membrane stabilization, manipulation of the cycloxygenase and lipoxygenase reactions, and the use of free radical scavengers.
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