Anti-HIV-1 protease activities of crude extracts of some Garcinia species growing in Tanzania
Magadula, J.J.; Tewtrakul, S.
African Journal of Biotechnology 9(12): 1848-1852
2010
ISSN/ISBN: 1684-5315 Document Number: 213577
Eighteenth ethanol extracts from some Garcinia species in the Guttiferae (Clusiaceae) family collected in Tanzania were investigated for their HIV-1 protease (HIV-1 PR) inhibitory activities using high performance liquid chromatography (HPLC). Among the tested extracts, the fruit hulls of Garcinia semseii showed the most potent inhibitory activity against HIV-1 PR with an IC50 value of 5.7 mu g/ml followed by the stem bark extracts of Garcinia edulis and Garcinia kingaensis with IC50 values of 9.2 and 15.2 mu g/ml, respectively. Phytochemical screening of extracts indicated mostly the presence of phenolic and steroidal compounds.