HIV-1 resistance in the Yamal region and the comparison of mutation frequency with various score values
Volova, L.I.; Grezina, L.A.; Ulanova, T.I.
Klinicheskaia Laboratornaia Diagnostika 2: 43-46
2010
ISSN/ISBN: 0869-2084 PMID: 20397579 Document Number: 213553
The amino acid sequence of the known strain HXB-2 belonging to subtype B is used as a reference strain matrix to determine HIV genotypic resistance by the sequencing technique. However, numerous studies have ascertained that HIV non-B subtypes have been widely accepted in Russia. The authors' data show that the significance of low score mutations in the Russian populations of HIV-1 is yet to be explained, unquestionably, arouses great scientific interest, and calls for further study.