Relationship between chemical structure and allergenicity: aromatic amines
Malkowski, J.; Klenieswka, D.; Maibach, H.
Dermatosen in Beruf und Umwelt. Occupation and Environment 31(2): 48-50
1983
ISSN/ISBN: 0343-2432 PMID: 6861644 Document Number: 213536
This review utilizes current clinical and experimental contact sensitization data with aromatic amines to hypothesize on the relationship between chemical structure and allergenicity. The available data suggests: 1. A Primary amino group in the ring induces sensitizing properties; 2. aromatic amine allergenicity is related to basicity, resulting from the action of substituents in the ring; 3. electron donor substituents enhance whereas electron acceptor substituents attenuate the activity.