Reduction of serum triacylglycerol-rich lipoprotein concentrations in cows with hepatic lipidosis
Herdt, T.H.; Liesman, J.S.; Gerloff, B.J.; Emery, R.S.
American Journal of Veterinary Research 44(2): 293-296
1983
ISSN/ISBN: 0002-9645 PMID: 6830020 Document Number: 213294
The hepatic and serum lipid concentrations were measured in 49 dairy cows with displaced abomasum, 7 postpartum cows starved for 6 days, and 14 healthy postpartum cows. The cows with displaced abomasum were retrospectively allotted to 2 groups: those with greater than 15% (DAHF) and those with less than 15% liver fat (DALF). Liver total lipid concentrations were high in the DAHF group, exceeding these values in the starved cows by 30% and in the healthy and DALF cows by 63% on the average. In contrast, the liver phospholipid concentrations were low in the DAHF group, intermediate in the starved and DALF groups and high in the healthy group. Within the groups, there was an inverse relationship between serum and liver lipid concentrations. The serum concentrations of both total and dextran-sulphate-precipited (DSP) lipids were high in the starved cows and were less in the DALF and healthy cows and in the DAHF cows (lowest). The between-group differences in serum total and serum DSP concentrations of triacylglycerol, cholesterol, and phospholipid followed the same quantitative pattern as the total lipids. However, the relative difference between groups was greater for each of the DSP lipid fractions. These results support the hypothesis that severe hepatic lipidosis in cattle is caused by impaired hepatic lipoprotein synthesis and secretion.