Anti-HIV-1 efficacy of extracts from medicinal plants
Lee, S.-A.; Hong, S.-K.; Suh, C.-I.; Oh, M.-H.; Park, J.-H.; Choi, B.-W.; Park, S.-W.; Paik, S.-Y.
Journal of Microbiology 48(2): 249-252
2010
ISSN/ISBN: 1976-3794 PMID: 20437159 DOI: 10.1007/s12275-009-0176-9Document Number: 212721
The anti-HIV-1 activities of butanol, hexane, chloroform and water extracts from four widely used folk medicinal plants (Sophora flavescens, Tulipa edulis, Herba ephedra, and Pachyma hoelen Rumph) were evaluated in this study. The hexane extract of Pachyma hoelen Rumph, PH-4, showed effective inhibition against HIV-1. The 50% effective concentration (EC(50)) of PH-4 was 37.3 microg/ml in the p24 antigen assay and 36.8% in the HIV-1 recombinant RT activity test (at 200 microg/ml). In addition, the PH-4 showed the protective effect on the infected MT-4 cells, with a 58.2% rate of protection. The 50% cytotoxic concentration (CC(50)) of PH-4 was 100.6 microg/ml. These results suggest that PH-4 from Pachyma hoelen Rumph might be the candidate for the chemotherapy agent against HIV-1 infection with further study.
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