Radioimmunological study of the antigen and antibody dynamics of viral hepatitis a and B patients
Reĭnaru, I.K.; Belokon, V.N.; Pavlovskiĭ, G.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 58-61
1983
ISSN/ISBN: 0372-9311 PMID: 6306963 Document Number: 212535
The combined radioimmunoassay of changes in the levels of HBsAg, HBaAb, HBcAb and HAAb in 34 patients with viral hepatitis, as well as in 8 patients with chronic hepatitis and in 40 normal persons, was carried out. Radioimmunoassay was made with the use of reagents manufactured by Abbot Laboratories (USA). This study showed that in infectious hepatitis the levels of HAAb in all patients were elevated already in the first decade of the disease and reached their maximum by the third decade. In serum hepatitis the high levels of HBsAg and HBcAb were observed during the acute period of the disease, while the content of HBsAb did not exceed the normal level. In some of the patients with virial hepatitis the levels of the antigens characteristic of both hepatitis B (HBsAg, HBcAb) and hepatitis A (HAAb) were elevated simultaneously.