Controlled trial of monthly alternated courses of steroid and chlorambucil for idiopathic membranous nephropathy
Ponticelli, C.; Zucchelli, P.; Imbasciati, E.; Cagnoli, L.; Pozzi, C.; Grassi, C.; Limido, D.; Pasquali, S.; Passerini, P.; Volpini, T.; Locatelli, F.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 19: 717-723
1983
ISSN/ISBN: 0071-2736 PMID: 6348763 Document Number: 212389
Forty-nine patients with membranous nephropathy (MN) and nephrotic syndrome (NS) were randomly allocated to supportive or specific therapy. The latter consisted of steroids or chlorambucil given in alternate months for a cumulative period of six months. Three patients in the experimental group were dropped from the study because of therapy related side-effects. At the end of follow-up there were significantly more patients in complete or partial remission in the experimental group than in the controls. The mean serum creatinine did not change in treated patients, but it significantly increased in controls.