Top Abstract Purchase Related
Home
>
Node
>
Subnode

A modified form of mitochondrial hexokinase produced by ATP-induced solubilization

Ureta, T.; Radojković, J.; Bustamante, E.

Biochemistry International 7(5): 585-592

1983

ISSN/ISBN: 0158-5231
PMID: 6679748
Document Number: 212268
Mitochondrial hexokinases from several rat tissues were analyzed by DEAE-cellulose chromatography. Solubilization by glucose-6-P or Triton X-100 released hexokinases A and B. Solubilization by ATP resulted in a decrease of hexokinase A and the concomitant appearance of a new fraction of lower net charge (hexokinase Am) which readily reverts to hexokinase A by dialysis or dilution. Treatment of homogeneous or partially purified hexokinase A with ATP did not generate hexokinase Am. Hexokinases Am and A were equally inhibited by an anti-hexokinase immune serum and displayed the same Km values for glucose and ATP. Hexokinase Am may represent a conformer or an oligomer produced during ATP-induced solubilization of hexokinase A from mitochondria.

Document emailed within 1 workday
Secure & encrypted payments

Okada, M.; Uchimura, N.; Ohe, R. 1988: Abnormal molecules of mitochondrial aspartate aminotransferase in the liver of vitamin B-6--deficient rats may be produced in the mitochondrial matrix Journal of Nutrition 118(5): 609-612
Goncharova, N.I.; Zelenina, E.V.; Avramova, L.V. 1994: Hexokinase isoenzyme Ii has a segment responsible for specific interaction of the enzyme with mitochondrial membranes Biokhimiia 59(6): 826-837
Jeffs, R.A.; Cooper, C.L.; Harden, T.K. 1991: Solubilization of a guanine nucleotide-sensitive form of the P2Y-purinergic receptor Molecular Pharmacology 40(1): 85-92
Howell, D.M.; Martz, E. 1987: The degree of CTL-induced DNA solubilization is not determined by the human vs mouse origin of the target cell Journal of Immunology 138(11): 3695-3698
Mitchell, C.A.; Kelemen, S.M.; Salem, H.H. 1988: The anticoagulant properties of a modified form of protein S Thrombosis and Haemostasis 60(2): 298-304
Miccoli, L.; Beurdeley-Thomas, A.; De Pinieux, G.; Sureau, F.; Oudard, S.; Dutrillaux, B.; Poupon, M.F. 1998: Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria Cancer Research 58(24): 5777-5786
Peng, J.; Lapolla, S.M.; Zhang, Z.; Lin, J. 2009: The cytosolic domain of Bcl-2 oligomerizes to form pores in model mitochondrial outer membrane at acidic pH Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26(3): 631-637
Wakabayashi, S.; Hatefi, Y. 1987: Amino acid sequence of the NAD (H)--binding region of the mitochondrial nicotinamide nucleotide transhydrogenase modified by N,N'-dicyclohexylcarbodiimide Biochemistry International 15(3): 667-675
Szymczyk, P.; Junka, A.; Ziółkowski, G.; Smutnicka, D.; Bartoszewicz, M.; Chlebus, E. 2013: The ability of S.aureus to form biofilm on the Ti-6Al-7Nb scaffolds produced by Selective Laser Melting and subjected to the different types of surface modifications Acta of Bioengineering and Biomechanics 15(1): 69-76
Ohta, S. 1995: Mitochondrial diseases caused by mitochondrial DNA mutants and their related regulation of mitochondrial biogenesis Seikagaku. Journal of Japanese Biochemical Society 67(1): 15-32
Novikova, L.A.; Savel'ev, A.S.; Zviagil'skaia, R.A.; Luzikov, V.N. 1995: Import of a modified form of a cytochrome P450scc precursor into mitochondria from various sources Biokhimiia 60(7): 995-1004
Niwa, T.; Aiuchi, T.; Nakaya, K.; Emoto, Y.; Miyazaki, T.; Maeda, K. 1993: Inhibition of mitochondrial respiration by furancarboxylic acid accumulated in uremic serum in its albumin-bound and non-dialyzable form Clinical Nephrology 39(2): 92-96
Marsac, C.; Degoul, F.; Bonne, G.; Romero, N.; Nelson, I.; Fardeau, M.; François, D.; Ponsot, G.; Harpey, J.P.; Eymard, B. 1991: Mitochondrial function and mitochondrial DNA in a series of 64 patients suspected of having mitochondrial myopathy Revue Neurologique (Paris) 147(6-7): 462-466
Inamori, M.; Ishigami, T.; Takahashi, N.; Hibi, K.; Ashino, K.; Sumita, S.; Tamura, K.; Ochiai, H.; Umemura, S.; Ishii, M.; Tanaka, S.; Sekihara, H.; Inayama, Y. 1997: A case of mitochondrial cardiomyopathy with heart failure, sick sinus syndrome and diabetes mellitus: mitochondrial DNA adenine-to-guanine transition at 3243 of mitochondrial tRNA(LEU)(UUR) gene Journal of Cardiology 30(6): 341-347
Pover, G.M.; Dash, C.H. 1985: A new, modified form of inhaler ('Rotahaler') for patients with chronic obstructive lung disease Pharmatherapeutica 4(2): 98-101
Vattikonda, C.S.; Ritschel, W.A.; Herbert, C. 1994: Biopharmaceutic approach in designing a controlled release tablet of sodium monofluoro phosphate. Characterization of absorption sites and evaluation of modified dosage form International Journal of Clinical Pharmacology and Therapeutics 32(10): 559-566
Brown, A.L.; Merry, D.L.; Beckenhauer, W.H. 1973: Modified live-virus rabies vaccine produced from flury high egg-passage virus grown on an established canine-kidney cell line: three-year duration-of-immunity study in dogs American Journal of Veterinary Research 34(11): 1427-1432
Kamiike, W.; Shimizu, S.; Hatanaka, N.; Morimoto, Y.; Nishida, T.; Miyata, M.; Yoshida, Y.; Matsuda, H. 1995: Effect of intracellular pH on reoxygenation-induced mitochondrial damage Transplantation Proceedings 27(1): 531-532
Fujii, S.; Konishi, I.; Okamura, H.; Kawaguchi, K.; Ida, K. 1984: Histogenetic considerations of experimentally induced adenomatoid tumor-like nodules produced by sex steroids Nihon Sanka Fujinka Gakkai Zasshi 36(1): 1-7
Yasui, L.S.; Hofer, K.G. 1986: Role of mitochondrial DNA in cell death induced by 125I decay International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 49(4): 601-610