NZB cells actively interfere with the establishment of tolerance to BGG in radiation chimeras
Laskin, C.A.; Smathers, P.A.; Lieberman, R.; Steinberg, A.D.
Journal of Immunology 131(3): 1121-1125
1983
ISSN/ISBN: 0022-1767 PMID: 6193177 Document Number: 212240
We report experiments designed to determine if the tolerance defect in NZB mice results from i) failure of NZB cells to become tolerant, or ii) the ability of NZB cells to interfere actively with the development of tolerance. The results indicate that NZB cells are primed by the tolerogen itself and actively interfere with the expression of tolerance by DBA/2 cells, which normally can be rendered tolerant.