Recovery of thyroid function with a decreased titre of antimicrosomal antibody in a hypothyroid man with Hashimoto's thyroiditis
Yamamoto, M.; Kaise, K.; Kitaoka, H.; Yoshida, K.; Kaise, N.; Fukazawa, H.; Sakurada, T.; Saito, S.; Yoshinaga, K.
Acta Endocrinologica 102(4): 531-534
1983
ISSN/ISBN: 0001-5598 PMID: 6687775 Document Number: 211816
A 36 yr old man with a diffuse goiter, signs of mild hypothyroidism, srinkingly low levels of T4 (24 ng/dl), elevated TSH (140 .mu.U/ml) and elevated microsomal hemagglutination antibody (MCHA, 1:409,600), subsequently became non-goitrous and euthyroid with a decreased titer of antimicrosomal antibody without any medication. At the time of surgical biopsy, serum levels of T4 and T3 had risen to the normal range (4.6 .mu.g/dl and 73 ng/dl, respectively), serum TSH had decreased to 30 .mu.U/ml and the titer of MCHA to 1:25,600. Thyroid specimens showed Hashimoto's thyroiditis. The activity of thyroid peroxidase (TPO) was normal. The latest examination, 1 yr and 3 mo. after initital evaluation, showed that the patient remained euthyroid with no goiter, that serum thyroid hormones were within the normal range (T4 7.7 .mu.g/dl and T3 97 ng/dl), and that TSH was not detectable. The titer of MCHA decreased strikingly to 1:400.