Clinical polymorphism in a familial case of demyelinating disease
Alaev, B.A.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 83(3): 24-27
1983
ISSN/ISBN: 0044-4588 PMID: 6222573 Document Number: 210913
A family of non-indigenous inhabitants of Uzbekistan whose three generations have produced three cases of demyelinizing disease are described. One female patient was born, while the other two have been living in the South of Uzbekistan for a long period of time. Multiple lesions of the nervous system, spontaneous and drug-induced remissions in the course of the disease constituted a clinical picture similar to that seen in disseminated sclerosis. The polymorphism of the neurologic signs combined with affections of different endocrine organs in each patient showed a predisposing role of the genetic mechanism in a possible impact of damaging exogenous factors.