Factors associated with poor adherence to anti-retroviral therapy in patients attending a rural health centre in South Africa
Bhat, V.G.; Ramburuth, M.; Singh, M.; Titi, O.; Antony, A.P.; Chiya, L.; Irusen, E.M.; Mtyapi, P.P.; Mofoka, M.E.; Zibeke, A.; Chere-Sao, L.A.; Gwadiso, N.; Sethathi, N.C.; Mbondwana, S.R.; Msengana, M.
European Journal of Clinical Microbiology and Infectious Diseases Official Publication of the European Society of Clinical Microbiology 29(8): 947-953
2010
ISSN/ISBN: 1435-4373 PMID: 20467769 DOI: 10.1007/s10096-010-0949-4Document Number: 210781
South Africa has a very high HIV disease burden and proper patient adherence to anti-retroviral therapy (ART) is crucial in achieving optimal treatment outcomes. Factors influencing adherence include demographic and psychosocial factors, medication-related issues and other patient-related matters. This study was carried out in order to determine factors associated with poor compliance to anti-retroviral (ARV) medications in a rural setting. This interview-based descriptive and analytical study was carried out in a health centre where 168 patients who received ARVs were interviewed with pre-structured questionnaires, which covered various important compliance-related aspects. The results showed that 37.5% of the patients were non-adherent. Amongst men, poor adherence was seen in those who were single (48.9%), with tertiary education (60%), in those who consumed alcohol regularly (47.1%) and in those who were unemployed (56.1%). Higher rates of non-adherence in women was associated with being single (36.5%) and in those who used alcohol (60.7%). Medication-related adverse effects were reported in 47% of patients, notably, neuropathy, headache, nausea, loss of memory, diarrhoea and fatigue. Common reasons for missing doses were: being away from home (57.1%), simply forgot (41.3%), side effects (50.8%) and being too busy (49.2%). Poor adherence to ART is an important concern relating to HIV management in our setting and needs to be addressed with more patient-oriented interventions.
Document emailed within 0-6 h
