Chromosome changes in patients with chronic benzene poisoning
Ding, X.J.; Li, Y.; Ding, Y.; Yang, H.Z.
Chinese Medical Journal 96(9): 681-685
1983
ISSN/ISBN: 0366-6999 PMID: 6418466 Document Number: 208258
Chromosome changes are studied in 21 cases of chronic benzene poisoning, both hypodiploid and hyperdiploid cells are significantly increased. Among the hypodiploid cells, deletion of Group C, E and G chromosomes is observed. Analysis of hyperdiploid cells reveals extra Group C and E chromosomes. The chromatid gaps and breaks are mostly found in poison cases, but fragments and minutes are less common. The chromosome abnormalities induced by chronic benzene intoxication may be considered further proof of benzene metabolite acting chiefly through changes in the nucleic acid metabolism.