Blood level kinetics of sodium noramidopyrine methanesulfonate (Analgin) in late pregnancy
Peiker, G.; Müller, B.; Voigt, G.; Nöschel, H.
Die Pharmazie 38(6): 406-408
1983
ISSN/ISBN: 0031-7144 PMID: 6611643 Document Number: 208037
The pharmacokinetic parameters were investigated after a single application of 1,0 g of Analgin to women in labour in comparison with a nonpregnant control group. During the late stage of pregnancy the distribution volume is only slightly increasing. For Analgin a fundamental influence on the level of serum concentration could not be shown. The biological half-life of Analgin shows remarkable individual differences and does not differ significantly between the two investigated groups. Therefore, during pregnancy a change of the applied dose is not indicated.