Autopsy case of atypical medulloblastoma in an adult
Nakamura, T.; Matsubara, O.; Miyazaki, M.; Kasuga, T.; Kamiyama, R.; Nakamura, T.; Fujimoto, T.; Inaba, Y.
Gan no Rinsho. Japan Journal of Cancer Clinics 29(14): 1651-1656
1983
ISSN/ISBN: 0021-4949 PMID: 6663712 Document Number: 207993
A 24-year-old female complained of headache and vomiting. The brain-CT scan demonstrated a tumor shadow in the right cerebellar hemisphere. The tumor was partially resected, and irradiation therapy was started. She died of intraventricular hemorrhage about 6 months after the onset of symptoms. Autopsy revealed a recurrent tumor mass in the cerebellum extending to the brain stem. It showed systemic metastases to the leptomeninx, liver, bones and ovaries. Histological examination showed a tumor which was a primarily composed of typical medulloblastoma cells with occasional Homer-Wright type rosettes. It partly showed glioblastoma-like configuration. Some tumor cells were positive for GFAP by the PAP method, suggesting glial differentiation.