Cefotiam passage into the maxillary sinus tissues
Nakashima, M.; Ikoma, H.; Yokoyama, M.; Suzuki, T.; Sugihara, S.
Japanese Journal of Antibiotics 36(10): 2730-2732
1983
ISSN/ISBN: 0368-2781 PMID: 6325743 Document Number: 206973
Clinical study was made on cefotiam (CTM) and the following results were obtained. Tissue concentrations of CTM were determined 1 hour after intravenous injection (CTM 1 g) in chronic sinusitis and maxillary cyst. Concentrations of CTM were 16.53 micrograms/g, 13.26 micrograms/g in mucosa of the maxillary sinus, maxillary cyst, respectively. Antibacterial activity of CTM was measured on Escherichia coli, Staphylococcus epidermidis, Aerococcus, Acidaminococcus fermentans, Peptostreptococcus anaerobius; that were isolated from pus of maxillary sinus. The highest MIC on them was 3.13 micrograms/ml.