Obstetric and perinatal outcome in HIV positive women receiving HAART in urban Nigeria
Olagbuji, B.N.; Ezeanochie, M.C.; Ande, A.B.; Oboro, V.O.
Archives of Gynecology and Obstetrics 281(6): 991-994
2010
ISSN/ISBN: 1432-0711 PMID: 19629507 DOI: 10.1007/s00404-009-1186-xDocument Number: 206703
To compare the outcome of pregnancy between HIV positive pregnant women on highly active antiretroviral therapy (HAART) and HIV negative controls. A prospective matched case-control study. HIV positive women were significantly more likely to have anaemia in pregnancy [p < 0.001, odds ratio (95% CI) 5.66 (3.0-10.5)], intrauterine growth restriction [p = 0.002, odds ratio (95%CI) 13.82 (1.8-106.7)], preterm labour [p = 0.03, odds ratio (95% CI) 2.89 (1.2-7.0)] and birth weight less than 2,500 g [p < 0.0001, odds ratio (95% CI) 5.43 (2.4-12.0)]. The 5-min apgar score less than 7, admission into neonatal unit, stillbirth and perinatal mortality were comparable between the two groups. Anaemia in pregnancy, intrauterine growth restriction, preterm labour and birth weight less than 2,500 g are important complications among HIV positive pregnant women. This information is vital for strategic antenatal care planning to improve obstetric and perinatal outcome in these women.
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