Effect of anesthesia on blood concentration of cyclic nucleotides and their role in the metabolism of humoral mediators in the lungs
Gimmel'farb, G.N.; Gerasimov, N.M.; Nazyrova, L.A.
Vestnik Khirurgii Imeni I. I. Grekova 130(6): 102-105
1983
ISSN/ISBN: 0042-4625 PMID: 6310842 Document Number: 206399
The contents of cAMP and cGMP, adrenaline, noradrenaline and serotonin in the blood were studied in 96 patients with surgical pathology of lungs. Anesthesia and intraoperative factors were shown to result in a gradual increase of the cAMP concentration followed by the histamine release from the pulmonary tissue. It is associated with an increased pulmonary-arterial and pulmonary-capillary pressure when getting out of narcosis and in the restoration of spontaneous respiration.