The genetics of transformation by SV 40
Feunteun, J.; Petit, C.A.
Archiv für Geschwulstforschung 53(4): 301-302
1983
ISSN/ISBN: 0003-911X PMID: 6312919 Document Number: 206101
Experiments using the tsA 58 allele of the SV 40-A gene have demonstrated that the SV 40 large T-antigen is strictly required both for immortalization and induction anchorage independence of cells. It has been suggested that the immortalized phenotype is mediated by an extra cellular factor. The synthesis and/or the excretion of this factor in a medium is controlled by the A gene.