Influence of macrophage culture supernatants on erythroblastic islets in rat erythropoiesis
Zakharov, Y.; Prenant, M.
Nouvelle Revue Francaise d'Hematologie 25(1): 17-22
1983
ISSN/ISBN: 0029-4810 PMID: 6835833 Document Number: 205256
The isolation of central macrophages from erythroblastic islands (EI) permitted analysis of the role of EI macrophage factors in erythropoiesis. EI macrophage supernatant and peritoneal macrophage supernatant both had a similar effect on erythropoiesis. They exerted an erythropoietin-like effect. We observed changes in the number of erythroblasts per island; their distribution within each island during the maturation process was described. The role of the central macrophage in EI was discussed. We suggested a direct transfer of an erythropoietin-like activity to the erythroblasts which increases the efficacy of stimulation.