Piperacillin concentration in the pelvic dead space exudate following surgery of cervical cancer
Koike, K.; Ohshima, T.
Japanese Journal of Antibiotics 36(10): 2820-2824
1983
ISSN/ISBN: 0368-2781 PMID: 6674517 Document Number: 205209
Twelve patients with uterocervical cancer had panhysterectomy and were administered piperacillin (PIPC) at a dose of 2 g by one shot injection 2 times a day for a period of 5--6 days. PIPC concentrations in serum and pelvic dead space exudate were investigated before and after administration for 3 days (5 times). Serum concentration was observed ca. 49 micrograms/ml at 1 hour after the first, third and fifth administration. Concentrations in pelvic dead space exudate at 1 hour after the first, third and fifth administration were observed 26.7 +/- 5.8, 10.8 +/- 4.0 and 8.7 +/- 3.5 micrograms/ml, respectively. The highest concentration was 63.0 micrograms/ml at 1 hour after the first administration in case 4. It was thought that these concentrations were sufficient for the therapy of parametritis. No side effects caused by the drug were observed.