The effect of tamoxifen in intermediate alpha 1-antitrypsin deficiency associated with the phenotype PiSZ
Eriksson, S.
Annals of Clinical Research 15(2): 95-98
1983
ISSN/ISBN: 0003-4762 PMID: 6603815 Document Number: 204759
Three patients, one with lung disease and two with liver disease, with intermediate alpha 1-antitrypsin (AAT) deficiency phenotype PiSZ, (plasma AAT concentration approximately 1/3 of normal) were treated with the anti-oestrogen drug, tamoxifen, for 2-24 months. Patients responded with 50-70% increases in plasma AAT concentrations. Progress of emphysema appeared to be retarded in one case but no improvement in liver function was recorded in the other two patients.