Ventricular hypertrophy in sinoaortic denervated rats
Cabral, A.M.; Vásquez, E.C.; Mill, J.G.; Futuro-Neto, H.A.
Brazilian Journal of Medical and Biological Research 16(4): 353-356
1983
ISSN/ISBN: 0100-879X PMID: 6231969 Document Number: 204613
Sinoaortic denervation (SAD) induced a significant increase in mean arterial pressure in male (122 +/- 3 mmHg) and female (126 +/- 3 mmHg) rats compared to male (103 +/- 2 mmHg) and female (106 +/- 3 mmHg) sham-operated (SO) controls (P less than 0.05). A significant increase of the weight of the left ventricle (LV) (11.5%, P less than 0.001) was observed 15 days after surgery in male, but not in female, SAD hypertensive rats compared to pair-fed SO controls. The data suggest that hormonal factors contribute to rapid LV hypertrophy in male SAD hypertensive rats.