In vitro anti-HIV-1 properties of ethnobotanically selected South African plants used in the treatment of sexually transmitted diseases
Tshikalange, T.E.; Meyer, J.J.M.; Lall, N.; Muñoz, E.; Sancho, R.; Van de Venter, M.; Oosthuizen, V.
Journal of Ethnopharmacology 119(3): 478-481
2008
ISSN/ISBN: 0378-8741 PMID: 18809485 DOI: 10.1016/j.jep.2008.08.027Document Number: 203906
Ethopharmacological relevance: The plants selected in this study are used traditionally in the treatment of sexually transmitted diseases and traditional healers interviewed claimed these plants can also help AIDS patients. Aim: To evaluating the in vitro anti-HIV properties of selected plants in various bioassays. Materials and Methods: The extracts were evaluated for their inhibition against alpha -glycohydrolase, reverse transcriptase and viral proteins (NF- kappa B and Tat) which play a significant role in the HIV life cycle. Results: Terminalia sericea extract (IC50=92 mg/ml) exhibited a considerable alpha -glucosidase inhibitory activity which was better than acarbose (IC50=131 mg/ml) under our assay conditions. In the reverse transcriptase assay, T. sericea also showed good inhibitory activity (IC50=43 mg/ml), which was higher than that of the reference drug, Adriamycin (IC50=100 mg/ml). The ethyl acetate extract of Elaeodendron transvaalense exhibited the most potent inhibitory activity in both the NF- kappa B and Tat assays with inhibitory activity of 76% and 75% respectively at a concentration of 15 mg/ml. The acetone and chloroform extracts of E. transvaalense and Zanthoxylum davyi also showed good activity in the NF- kappa B and Tat assays.
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