Experimental and clinical evaluation of cefotetan in pediatrics
Aoyama, R.; Kakizaki, Y.; Ohnishi, A.; Izumi, Y.; Fujita, M.; Nagata, K.; Asuka, N.; Kudo, M.; Chiba, C.; Tsushima, N.
Japanese Journal of Antibiotics 36(6): 1191-1198
1983
ISSN/ISBN: 0368-2781 PMID: 6581325 Document Number: 202912
Basic and clinical studies on cefotetan (CTT) were carried out and the results were as follows: Absorption and excretion Two patients were given 10 mg/kg of CTT by one shot intravenous injection. At 30 minutes after injection, mean serum level was 76.5 micrograms/ml and the half-life time was 2.3 hours. Mean 6-hour urinary recovery in same patients was 57.5%. Clinical evaluation Forty-two patients were treated with CTT, in doses of 19.2-102.9 mg/kg divided 2-4 times per day for 3-10 days intravenously. Responses were excellent in 14, good in 23, fair in 1, poor in 4, and the overall efficacy rate was 88.1%. As to adverse reaction, urticaria was observed in 1 patient. Abnormal laboratory data noted were elevation of GOT in 1, GOT and GPT in 2, creatinine in 1, and eosinophilia in 3 patients.