Evaluation of cardiovascular morbidity in Nigerian women after 3 years of Norplant contraception
Sagay, A.S.; Okeahialam, B.N.; Imade, G.E.; Aisien, A.O.
African journal of reproductive health 12(1): 47-53
2008
ISSN/ISBN: 1118-4841 PMID: 20695154 Document Number: 202817
This study was conducted to determine any cardiovascular morbidity with Norplant use by electrocardiography. Thirty Nigerian women seeking long-term reversible contraception were recruited. The clients had baseline blood pressure checks and electrocardiography (ECG) tracings. These were repeated at the 12, 24 and 36 months follow-up visits and the results were analysed. The mean age of subjects was 32.4 +/- 3.98 years. The mean weight at pre-insertion and at the 12, 24 and 36 months follow-up visits showed a statistically significant rise after 2 years (p < 0.01). The blood pressures did not show any significant changes throughout the period of study. There was statistically significant prolongation of the PR and QRS intervals at the 12 month visit; mean PR interval (seconds) pre-insertion 0.153 +/- 0.003, and at 12 months 0.173 +/- 0.006 (P = 0.019), mean QRS interval (seconds) pre-insertion 0.056 +/- 0.003 and at 12 months 0.074 +/- 0.002 (P = 0.005). After 3 years of Norplant use, prolongation of the mean QRS interval remained evident (p = 0.011) while mean PR interval had returned to pre-insertion levels. There is a tendency to prolongation of PR and QRS (ECG) intervals in Norplant users; accordingly, it may be prudent for clients with cardiac conditions showing longer ECG intervals, to consider alternative methods of contraception.