Experimental murine infections with a Mycobacterium avium-intracellulare complex organism isolated from mice
Waggie, K.S.; Wagner, J.E.; Lentsch, R.H.
Laboratory Animal Science 33(3): 254-257
1983
ISSN/ISBN: 0023-6764 PMID: 6876730 Document Number: 202775
B6C3F1 hybrid mice did not develop lesions of mycobacterial infection when inoculated intratracheally with M. avium-intracellulare complex isolated from a natural outbreak in C57BL/6N mice in a B6C3F1 hybrid production colony. Young C57BL/6N females did not develop lesions when caged with naturally infected adult C57BL/6N mice. After s/c or oral inoculation of the isolate into 8-week-old and adult 36- to 40-week-old C57BL/6N mice, it was found that the s/c route yielded more culture positive lungs and animals with gross and microscopic pulmonary lesions than the oral inoculation. Adults were more susceptible to infection than 8-week-old animals.