Platelet abnormalities in muscular dystrophy
Yarom, R.; Meyer, S.; More, R.; Liebergall, M.; Eldor, A.
Thrombosis and Haemostasis 49(3): 168-172
1983
ISSN/ISBN: 0340-6245 PMID: 6308847 Document Number: 202744
Platelets which have complex membranes and calcium shifts similar to those in muscles were investigated in 14 patients with muscular dystrophy and 20 suitable controls. In 4 Duchenne and one limb-girdle dystrophy aggregations were done and found to be depressed with adrenaline and ADP. Electron microscopic and chemical examinations revealed an increased number of dense bodies, changed permeability and/or binding of cations and elevated intracellular calcium in all the 9 cases of Duchenne dystrophy while the 2 limb-girdle and 3 myotonic dystrophies varied. A two phase polymer separation system applied to fixed platelets of all patients and controls showed no abnormality of surface negative charge.