A model of the differentiation and relative incidence of glandular versus squamous cell neoplasia of the uterine cervix: connection between incidence and etiology
Leppäluoto, P.A.
Acta Obstetricia et Gynecologica Scandinavica 87(8): 800-803
2008
ISSN/ISBN: 0001-6349 PMID: 18704774 DOI: 10.1080/00016340802268807Document Number: 202634
It has remained unclear why cervical adenocarcinoma, as observed in consecutive screening, has rapidly increased during the past decades, while at the same time both that of squamous cell carcinoma (SCC) and the combined toll of adeno- and SCC have consistently decreased. Here it is argued that this might be ascribed to coitus-related changes in the cervicovaginal milieu, where the target cells become infected through a coital act. Frequent alterations in vaginal acidity and changing sexual habits in the era after the oral contraceptive pills and even after the introduction of erectile dysfunction medication, contribute to the pathogenetic scene.