Energy metabolism in the liver of young and old rats during starvation
Kosenko, E.A.; Kaminskiĭ, I.G.
Ukrainskii Biokhimicheskii Zhurnal 55(4): 425-430
1983
ISSN/ISBN: 0201-8470 PMID: 6623669 Document Number: 201194
The concentration of key intermediate products of energy metabolism is determined in the liver of young and old rats under normal conditions and 24h after fasting. A decrease in the stationary concentrations of glucose, glucose-6-phosphate, ATP, ADP and AMP and an increase in the concentrations of lactate, glutamate, alpha-glycerophosphate and Pi were found in the liver of rats in ageing. The carbohydrate metabolism response to fasting is also disturbed. The total content of adenine nucleotides it the rat liver during ageing is 25-30% lower. The deficit of adenine nucleotides is not associated with the activation of AMP-desaminase; it may result from both physiological and functional disturbances in the ageing liver.